- "Epinephrine Autoinjector. Used for intramuscular injection to revive unconscious casualties."
- — In-game description
The Epi-Pen is the only item that can instantly force a player out of unconsciousness and does this by administering epinephrine (adrenaline) into the player's muscles. The only other way for a player to awaken from unconsciousness is time.
Players travelling in groups of two or more may wish to have at least one player with one Epi-Pen in their inventory for use if a group member falls into unconsciousness from an attack.
The Epi-Pen, like the Blood Bag, can only be administered by another player. This is because a player unconscious cannot administer it on themselves. It is unknown if administering an Epi-Pen on another player will reward any humanity points.
The Epi-Pen is a common medical item that has a 14.29% chance of spawning in Hospitals. This is equal to 1 429 out of 10 000. A Cardboard Box (Medical) contains five Epi-Pens, among other medical items, and has a 0.99% chance of spawning - equal to 99 out of 10 000. A single Epi-Pen occupies one inventory slot.